|
KMID : 1007520120210041221
|
|
Food Science and Biotechnology
2012 Volume.21 No. 4 p.1221 ~ p.1225
|
|
|
Effect of the Licorice Flavonoid Isoliquiritigenin on the Sleep Architecture and Profile in Mice
|
|
Cho Sueng-Mok
Yoon Min-Seok
Kim Dong-Soo
Kim Jin-Soo
Yang Hey-jin
Lee Chang-Ho
Kim In-Ho
Makoto Shimizu
Han Dae-seok
|
|
|
Abstract
|
|
|
|
The sleep-promoting effect of isoliquiritigenin (ILTG) was investigated by analyzing the sleep architecture in mice. A hypnotic diazepam (DZP, 2 mg/kg) significantly decreased sleep latency by 39.7% and increased the amount of non-rapid eye movement sleep (NREMS) by 103.8% for the first 3 h after administration. ILTG (50 mg/kg) also produced a significant decrease in sleep latency (30.7%) and an increase in the amount of NREMS (61.1%). DZP significantly decreased delta (0.5-4 Hz) activity as compared with the vehicle; however, ILTG did not alter the delta activity. These results mean that ILTG induces sleep similar to physiological sleep without a decline in sleep quality.
|
|
|
KEYWORD
|
|
|
isoliquiritigenin, sleep-promoting effect, sleep architecture, electroencephalogram, electromyogram
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|